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World’s 1st drug to regrow teeth enters clinical trials
by 8DonCo Mon Sep 25, 2023 10:56 pm
The ability to regrow your own teeth could be just around the corner.
A team of scientists, led by a Japanese pharmaceutical startup, are getting set to start human trials on a new drug that has successfully grown new teeth in animal test subjects.
Toregem Biopharma is slated to begin clinical trials in July of next year after it succeeded growing new teeth in mice five years ago, the Japan Times reports.
Dr. Katsu Takahashi, a lead researcher on the project and head of the dentistry and oral surgery department at the Medical Research Institute Kitano Hospital, says “the idea of growing new teeth is every dentist’s dream.”
“I’ve been working on this since I was a graduate student,” he told Japan’s national daily news site, the Mainichi, earlier this year. “I was confident I’d be able to make it happen.”
In his research, which he’s been conducting at Kyoto University since 2005, Takahashi learned of a particular gene in mice that affects the growth of their teeth.
The antibody for this gene, USAG-1, can help stimulate tooth growth if it is suppressed – and scientists have since worked to develop a “neutralizing antibody medicine” that is able to block USAG-1.
Now, his team has been testing the theory that “blocking” this protein could grow more teeth.
After their successful tests on mice, the team went on to perform similarly positive trials on ferrets – animals who have a similar dental pattern to humans.
Now, testing will turn to healthy adult humans and, if all goes well, the team plans to hold a clinical trial for the drug from 2025 for children between two and six years old with anodontia – a rare genetic disorder that results in the absence of six or more baby and/or adult teeth.
According to the Japan Times, the children involved in the clinical trial will be injected with one dose of the drug to see if it induces teeth growth.
If successful, the medicine could be available for regulatory approval by 2030.
Takahashi hopes the new medicine could be just another option for those who don’t have a full set of teeth.
“In any case, we’re hoping to see a time when tooth-regrowth medicine is a third choice alongside dentures and implants,” Takahashi told Mainichi.
A team of scientists, led by a Japanese pharmaceutical startup, are getting set to start human trials on a new drug that has successfully grown new teeth in animal test subjects.
Toregem Biopharma is slated to begin clinical trials in July of next year after it succeeded growing new teeth in mice five years ago, the Japan Times reports.
Dr. Katsu Takahashi, a lead researcher on the project and head of the dentistry and oral surgery department at the Medical Research Institute Kitano Hospital, says “the idea of growing new teeth is every dentist’s dream.”
“I’ve been working on this since I was a graduate student,” he told Japan’s national daily news site, the Mainichi, earlier this year. “I was confident I’d be able to make it happen.”
In his research, which he’s been conducting at Kyoto University since 2005, Takahashi learned of a particular gene in mice that affects the growth of their teeth.
The antibody for this gene, USAG-1, can help stimulate tooth growth if it is suppressed – and scientists have since worked to develop a “neutralizing antibody medicine” that is able to block USAG-1.
Now, his team has been testing the theory that “blocking” this protein could grow more teeth.
After their successful tests on mice, the team went on to perform similarly positive trials on ferrets – animals who have a similar dental pattern to humans.
Now, testing will turn to healthy adult humans and, if all goes well, the team plans to hold a clinical trial for the drug from 2025 for children between two and six years old with anodontia – a rare genetic disorder that results in the absence of six or more baby and/or adult teeth.
According to the Japan Times, the children involved in the clinical trial will be injected with one dose of the drug to see if it induces teeth growth.
If successful, the medicine could be available for regulatory approval by 2030.
Takahashi hopes the new medicine could be just another option for those who don’t have a full set of teeth.
“In any case, we’re hoping to see a time when tooth-regrowth medicine is a third choice alongside dentures and implants,” Takahashi told Mainichi.
_________________
8DonCo
Re: World’s 1st drug to regrow teeth enters clinical trials
by TuTu Mon Sep 25, 2023 11:22 pm
Wow hay qua' .
TuTu
Re: World’s 1st drug to regrow teeth enters clinical trials
by saurieng2016 Tue Sep 26, 2023 7:35 am
vậy có thể là by 2030 các nha sĩ về implant là phải retire thôi và những nha sĩ đang tính học về implant thì nên suy nghĩ lại 
_________________
saurieng2016
Re: World’s 1st drug to regrow teeth enters clinical trials
by 8DonCo Tue Sep 26, 2023 9:10 am
saurieng2016 wrote:vậy có thể là by 2030 các nha sĩ về implant là phải retire thôi và những nha sĩ đang tính học về implant thì nên suy nghĩ lại
không nhanh vậy đâu chắc đời con cháu minh cũng như dental implant có 7,8 chục năm tới nay mới popular mà cũng đâu ai có khả năng , denture vân còn thông dụng
_________________
8DonCo
Re: World’s 1st drug to regrow teeth enters clinical trials
by ga10 Tue Sep 26, 2023 10:23 am
8DonCo wrote:saurieng2016 wrote:vậy có thể là by 2030 các nha sĩ về implant là phải retire thôi và những nha sĩ đang tính học về implant thì nên suy nghĩ lại
không nhanh vậy đâu chắc đời con cháu minh cũng như dental implant có 7,8 chục năm tới nay mới popular mà cũng đâu ai có khả năng , denture vân còn thông dụng
Đúng vậy thuốc này có work thì chắc giá cả cũng trên trời và cũng có những side effects. Giá cả out of pocket for implants bây giờ có good insurance trả 50% cũng khoảng $3K/each. Làm hàm răng giả nhiều tiền lắm.
0 biết thuốc này là thoa lên chổ gum of missing tooth hay thuốc uống vậy? Chắc phải là thưốc thoa chứ uống vô thì làm sao control chổ nào cần mọc thì mới mọc. Rủi ro uống vô nó mọc ngay giửa trán thì sao?
ga10
Re: World’s 1st drug to regrow teeth enters clinical trials
by 8DonCo Tue Sep 26, 2023 10:36 am
ga10 wrote:8DonCo wrote:saurieng2016 wrote:vậy có thể là by 2030 các nha sĩ về implant là phải retire thôi và những nha sĩ đang tính học về implant thì nên suy nghĩ lại
không nhanh vậy đâu chắc đời con cháu minh cũng như dental implant có 7,8 chục năm tới nay mới popular mà cũng đâu ai có khả năng , denture vân còn thông dụng
Đúng vậy thuốc này có work thì chắc giá cả cũng trên trời và cũng có những side effects. Giá cả out of pocket for implants bây giờ có good insurance trả 50% cũng khoảng $3K/each. Làm hàm răng giả nhiều tiền lắm.
0 biết thuốc này là thoa lên chổ gum of missing tooth hay thuốc uống vậy? Chắc phải là thưốc thoa chứ uống vô thì làm sao control chổ nào cần mọc thì mới mọc. Rủi ro uống vô nó mọc ngay giửa trán thì sao?
thoa vô chổ missing teeth rồi nó mọc lại
_________________
8DonCo
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